SANPROBI IBS, CAPSULES results in a reduction of abdominal pain, bloating, and normalization of bowel movements 20 PCS.

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At certain visits patients will undergo the tests measuring the intestinal permeability (blood and stool zonulin immunoenzymatic tests). kapsułka zawiera 1×10 10 CFU/g całkowitej liczba bakterii probiotycznych Lactobacillus paracasei 8700:2, Lactobacillus plantarum HEAL 9 i Lactobacillus plantarum HEAL 19 oraz 1,5 µg witaminy D3; Calprotectin has been widely used in contemporary clinical practice to monitor inflammation of the gut mucosa. Jej zadaniem jest ograniczenie przenikania do krwi bakterii patogennych oraz produkowanych przez nie toksycznych metabolitów.

W produkcie nie wykryto kazeiny (granica wykrywalności 0,06 mg/kg), odtłuszczonego mleka w proszku (granica wykrywalności 1,0 mg/kg), β-laktoglobuliny (granica wykrywalności 2,0 mg/kg). The intestinal barrier creates a protective wall between the human body and the outside world. Its most important task is the proper selection and absorption of nutrients beneficial for health, protection against toxins and their elimination from the body, preventing the entry of pathogens from the gastrointestinal tract into the body. In addition, the intestinal barrier performs important physiological functions in the human body, therefore the disruption of its structure can lead to increased permeability, promote the overloading of the immune and nervous system. Schmitz L, Ferrari N, Schwiertz A, Rusch K, Woestmann U, Mahabir E, Graf C. Impact of endurance exercise and probiotic supplementation on the intestinal microbiota: a cross-over pilot study. Pilot Feasibility Stud. 2019 Jun 8;5:76. doi: 10.1186/s40814-019-0459-9. eCollection 2019.kapsułka zawiera łącznie 2,5×10 9 CFU/g bakterii Bifidobacterium lactis W51, Lactobacillus brevis W63, Lactobacillus acidophilus W22, Bifidobacterium bifidum W23 i Lactococcus lactis W58; Bonnet F, Scheen A. Understanding and overcoming metformin gastrointestinal intolerance. Diabetes Obes Metab. 2017 Apr;19(4):473-481. doi: 10.1111/dom.12854. Epub 2017 Feb 22. Holland AM, Hyatt HW, Smuder AJ, Sollanek KJ, Morton AB, Roberts MD, Kavazis AN. Influence of endurance exercise training on antioxidant enzymes, tight junction proteins, and inflammatory markers in the rat ileum. BMC Res Notes. 2015 Sep 30;8:514. doi: 10.1186/s13104-015-1500-6. Participants were informed that the cardiorespiratory fitness test should take place for a minimum of 2 weeks after intense physical effort (marathon, ultramarathon). The research was carried out at the Department of Dietetics and Clinical Nutrition at the Faculty of Health Sciences of the Medical University of Bialystok, Fitness Club Maniac Gym in Bialystok, as well as at the Hematological Diagnostics Department and the Biochemical Diagnostics Department of the University Clinical Hospital in Bialystok.

Metformin, the first-line drug in the treatment of type 2 diabetes (T2DM), may cause dose dependent undesirable side-effects like diarrhea, abdominal pain, nausea or bloating which may affect up to 20 % of patients treated with this drug. The second visit was conducted at the Fitness Club Maniac Gym, where the cardiopulmonary fitness test and body composition analysis were carried out.Szulinska M, Loniewski I, van Hemert S, Sobieska M, Bogdanski P. Dose-Dependent Effects of Multispecies Probiotic Supplementation on the Lipopolysaccharide (LPS) Level and Cardiometabolic Profile in Obese Postmenopausal Women: A 12-Week Randomized Clinical Trial. Nutrients. 2018 Jun 15;10(6):773. doi: 10.3390/nu10060773.