Gonge G-2117 Tactile Discs, Multicolour

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WHAT YOU GET (SIZE/DIMENSIONS/COLORS): 6 Tactile Sensory Discs each approximately 5 inches ibn diameter featuring calming textures soft mop, flip-sequins, squishy sponge, colorful sand, colorful beads with hidden letters, and colorful balls with hidden shapes.

Yan Z, Zhang W, He Y, Gorczyca D, Xiang Y et al (2013) Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature 493:221–225 Yoshimura M, Jessell T (1990) Amino acid-mediated EPSPs at primary afferent synapses with substantia gelatinosa neurones in the rat spinal cord. J Physiol 430:315–335 newcommand{\vecs}[1]{\overset { \scriptstyle \rightharpoonup} {\mathbf{#1}}}\) \( \newcommand{\vecd}[1]{\overset{-\!-\!\rightharpoonup}{\vphantom{a}\smash{#1}}} \)\(\newcommand{\id}{\mathrm{id}}\) \( \newcommand{\Span}{\mathrm{span}}\) \( \newcommand{\kernel}{\mathrm{null}\,}\) \( \newcommand{\range}{\mathrm{range}\,}\) \( \newcommand{\RealPart}{\mathrm{Re}}\) \( \newcommand{\ImaginaryPart}{\mathrm{Im}}\) \( \newcommand{\Argument}{\mathrm{Arg}}\) \( \newcommand{\norm}[1]{\| #1 \|}\) \( \newcommand{\inner}[2]{\langle #1, #2 \rangle}\) \( \newcommand{\Span}{\mathrm{span}}\) \(\newcommand{\id}{\mathrm{id}}\) \( \newcommand{\Span}{\mathrm{span}}\) \( \newcommand{\kernel}{\mathrm{null}\,}\) \( \newcommand{\range}{\mathrm{range}\,}\) \( \newcommand{\RealPart}{\mathrm{Re}}\) \( \newcommand{\ImaginaryPart}{\mathrm{Im}}\) \( \newcommand{\Argument}{\mathrm{Arg}}\) \( \newcommand{\norm}[1]{\| #1 \|}\) \( \newcommand{\inner}[2]{\langle #1, #2 \rangle}\) \( \newcommand{\Span}{\mathrm{span}}\)\(\newcommand{\AA}{\unicode[.8,0]{x212B}}\)

PRODUCT INFORMATION: 12PCs. Large circle size: Φ27cm, small circle size: Φ11cm. Certificated Age: 3+. Recommended Age: 3-8 years old. Weight capacity: 50kg. Passed Certification: EN71-1-2-3. Maricich SM, Wellnitz SA, Nelson AM, Lesniak DR, Gerling GJ et al (2009) Merkel cells are essential for light-touch responses. Science 324:1580–1582 We’ve been playing with it for a few days now. Everyone loves the varied sensory experience as you walk from piece to piece. It’s sort of like an ever changing foot massage. Johnson KO (2001) The roles and functions of cutaneous mechanoreceptors. Curr Opin Neurobiol 11:455–461

Bymaster FP, Beedle EE, Findlay J, Gallagher PT, Krushinski JH et al (2003) Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake. Bioorg Med Chem Lett 13:4477–4480Hoke A, Ray M (2014) Rodent models of chemotherapy-induced peripheral neuropathy. ILAR J 54:273–281 Fagan BM, Cahusac PM (2001) Evidence for glutamate receptor mediated transmission at mechanoreceptors in the skin. Neuroreport 12:341–347 Price MP, Lewin GR, McIlwrath SL, Cheng C, Xie J et al (2000) The mammalian sodium channel BNC1 is required for normal touch sensation. Nature 407:1007–1011

Prigg T, Goldreich D, Carvell GE, Simons DJ (2002) Texture discrimination and unit recordings in the rat whisker/barrel system. Physiol Behav 77:671–675 TARGETED SKILLS: Students can build fine motor skills in their fingers and hands as they press, pinch, fidget, and squeeze. These actions help build up the small muscles in the hand – the same muscles used when holding a crayon, marker, or pencil! Majithia N, Loprinzi CL, Smith TJ (2016) New practical approaches to chemotherapy-induced neuropathic pain: prevention, assessment, and treatment. Oncology (Williston Park) 30:1020–1029 Rao RD, Michalak JC, Sloan JA, Loprinzi CL, Soori GS et al (2007) Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled, crossover trial (N00C3). Cancer 110:2110–2118Findlater GS, Cooksey EJ, Anand A, Paintal AS, Iggo A (1987) The effects of hypoxia on slowly adapting type I (SAI) cutaneous mechanoreceptors in the cat and rat. Somatosens Res 5:1–17 Tapper DN (1965) Stimulus-response relationships in the cutaneous slowly-adapting mechanoreceptor in hairy skin of the cat. Exp Neurol 13:364–385 Ikeda R, Cha M, Ling J, Jia Z, Coyle D, Gu JG (2014) Merkel cells transduce and encode tactile stimuli to drive Abeta-afferent impulses. Cell 157:664–675 PORTABLE SENSORY EXPERIENCE: A portable sensory tactile experience that may ease anxiety and stress. Each disc features a different texture that can calm the body and mind creating moments of mindfulness throughout the day at school, at-home, or on-the-go!

Tofthagen C, McAllister RD, Visovsky C (2013) Peripheral neuropathy caused by Paclitaxel and docetaxel: an evaluation and comparison of symptoms. J Adv Pract Oncol 4:204–215 Halata Z, Grim M, Bauman KI (2003) Friedrich Sigmund Merkel and his “Merkel cell”, morphology, development, and physiology: review and new results. Anat Rec A Discov Mol Cell Evol Biol 271:225–239 Baumann KI, Chan E, Halata Z, Senok SS, Yung WH (1996) An isolated rat vibrissal preparation with stable responses of slowly adapting mechanoreceptors. Neurosci Lett 213:1–4 Albers J, Chaudhry V, Cavaletti G, Donehower R (2007) Interventions for preventing neuropathy caused by cisplatin and related compounds. Cochrane Database Syst Rev 24:CD005228 Yamashita Y, Akaike N, Wakamori M, Ikeda I, Ogawa H (1992) Voltage-dependent currents in isolated single Merkel cells of rats. J Physiol 450:143–162FUN MATCHING GAME: With little matching circular toys prepared for the large discs, they feature the similar textured surfaces, pairing them together by feet can be challenging and fun when blindfolded (Eye mask included). Sang CN, Gracely RH, Max MB, Bennett GJ (1996) Capsaicin-evoked mechanical allodynia and hyperalgesia cross nerve territories. Evidence for a central mechanism. Anesthesiology 85:491–496 Diamond ME, von Heimendahl M, Knutsen PM, Kleinfeld D, Ahissar E (2008) ‘Where’ and ‘what’ in the whisker sensorimotor system. Nat Rev Neurosci 9:601–612