Electronic Cigar | Rechargeable E Cigar | 3 x Gold Cigar Flavour Ecigar | e Shisha Kit | Electronic Cigarette | USB Charging

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Worldwide, increasing numbers of young people are vaping. [76] [77] With access to e-cigarettes, young people's tobacco use has dropped by about 75%. [78] [79] [80] [81] a b Hedman, L; Galanti, MR; Ryk, L; Gilljam, H; Adermark, L (13 October 2021). "Electronic cigarette use and smoking cessation in cohort studies and randomized trials: A systematic review and meta-analysis". Tobacco Prevention and Cessation. European Network for Smoking and Tobacco Prevention. 7 (62): 62. doi: 10.18332/tpc/142320. PMC 8508281. PMID 34712864. Hayden McRobbie (2014). "Electronic cigarettes" (PDF). National Centre for Smoking Cessation and Training. pp.1–16.

It is commonly stated that the modern e-cigarette was invented in 2003 by Chinese pharmacist Hon Lik, but tobacco companies had been developing nicotine aerosol generation devices since as early as 1963. [242] Early prototypes & barriers to entry: 1920s – 90sa b Pepper, J. K.; Brewer, N. T. (2013). "Electronic nicotine delivery system (electronic cigarette) awareness, use, reactions and beliefs: a systematic review". Tobacco Control. 23 (5): 375–384. doi: 10.1136/tobaccocontrol-2013-051122. ISSN 0964-4563. PMC 4520227. PMID 24259045. A 2022 study showed that E-cigarettes could actually lead people to smoke tobacco. Because the nicotine in e-cigarettes is addicting, it can cause new smokers to try tobacco and can cause current smokers to revert to using cigarettes [93] While advertising of tobacco products is banned in most countries, television and radio e-cigarette advertising in several countries may be indirectly encouraging traditional cigarette use. [83] E-cigarette advertisements are also in magazines, newspapers, online, and in retail stores. [349] Between 2010 and 2014, e-cigarettes were second only to cigarettes as the top advertised product in magazines. [350] As cigarette companies have acquired the largest e-cigarette brands, they currently benefit from a dual market of smokers and e-cigarette users while simultaneously presenting themselves as agents of harm reduction. [124] This raises concerns about the appropriateness of endorsing a product that directly profits the tobacco industry. [124] There is no evidence that the cigarette brands are selling e-cigarettes as part of a plan to phase out traditional cigarettes, despite some stating to want to cooperate in "harm reduction". [83] E-cigarette advertising for using e-cigarettes as a quitting tool have been seen in the US, UK, and China, which have not been supported by regulatory bodies. [351] Nicotine is a parasympathomimetic stimulant [205] that binds to and activates nicotinic acetylcholine receptors in the brain, [149] which subsequently causes the release of dopamine and other neurotransmitters, such as norepinephrine, acetylcholine, serotonin, gamma-aminobutyric acid, glutamate, endorphins, [206] and several neuropeptides, including proopiomelanocortin-derived α-MSH and adrenocorticotropic hormone. [207] Corticotropin-releasing factor, Neuropeptide Y, orexins, and norepinephrine are involved in nicotine addiction. [208] Continuous exposure to nicotine can cause an increase in the number of nicotinic receptors, which is believed to be a result of receptor desensitization and subsequent receptor upregulation. [206]

a b c d e f g Orellana-Barrios, Menfil A.; Payne, Drew; Mulkey, Zachary; Nugent, Kenneth (2015). "Electronic cigarettes-a narrative review for clinicians". The American Journal of Medicine. 128 (7): 674–81. doi: 10.1016/j.amjmed.2015.01.033. ISSN 0002-9343. PMID 25731134.British American Tobacco, through their subsidiary Nicoventures, licensed a nicotine delivery system based on existing asthma inhaler technology from UK-based healthcare company Kind Consumer. [398] In September 2014 a product based on this named Voke obtained approval from the United Kingdom's Medicines and Healthcare Products Regulatory Agency. [399] a b c Cai, Hua; Wang, Chen (2017). "Graphical review: The redox dark side of e-cigarettes; exposure to oxidants and public health concerns". Redox Biology. 13: 402–406. doi: 10.1016/j.redox.2017.05.013. ISSN 2213-2317. PMC 5493817. PMID 28667909. a b c d Bals, Robert; Boyd, Jeanette; Esposito, Susanna; Foronjy, Robert; Hiemstra, Pieter; Jiménez-Ruiz, Carlos A.; Katsaounou, Paraskevi; Lindberg, Anne; Metz, Carlos; Schober, Wolfgang; Spira, Avrum; Blasi, Francesco (February 2019). "Electronic cigarettes: a task force report from the European Respiratory Society". European Respiratory Journal. 53 (2): 1801151. doi: 10.1183/13993003.01151-2018. ISSN 0903-1936. PMID 30464018. S2CID 53711734. The long-term effects of ECIG use are unknown, and there is therefore no evidence that ECIGs are safer than tobacco in the long term. Based on current knowledge, negative health effects cannot be ruled out.