PIHKAL: A Chemical Love Story

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However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Recreational use was observed shortly afterward and it was briefly manufactured and sold commercially under such names as "Erox" and "Nexus" in "head" / "smart" shops and adult video stores before being federally scheduled in 1995. [5] Shulgin probably (arguably) single handedly made the phenethylamine class of drugs, as a whole, available to the masses. Some specifics in the class more so than others since he didn't discover and synthesize all of them. Although he did rediscover (in a way) certain ones that were lost in the scientific journals. Ones abandoned, hypothesized but unsynthesized, "untasted." David Biello (March 20, 2008). "Self-Experimenters: Psychedelic Chemist Explores the Surreality of Inner Space, One Drug at a Time". Scientific American. Nature Publishing Group. eISSN 1946-7087. ISSN 0036-8733 . Retrieved October 10, 2020.DOM (2,5-dimethoxy-4-methylamphetamine), DOM being short for des oxy methyl, referring to the removal of the Oxygen atom from the Methoxy group on the "4" carbon. B can be tested using the Marquis Reagent (NIK ® test A) and will produce a yellow/green colour. However, extra caution is needed as 2C-I (another 2C drug with different effects) will also give a yellow/green colour using the Marquis Reagent (NIK ® test A). There are other drug testing kits available that can be used for further clarification of substances, but it is important to appreciate the limitations in determining the differences between the 2C series of drugs which includes 2C-B, 2C-D, 2C-E, 2C-I, and 2C-P. Smaller doses (under 15 mg) are reported to be useful as a sensory and aesthetic enhancer (in a manner somewhat similar to MDMA) while larger doses are reported to produce a distinct mind-manifesting psychedelic effect. It is important to understand the metabolism of 2C-B by the body and the potential implications this may have. 2C-B is metabolised by enzymes called monoamine oxidases (MAOs) A and B, and therefore this could pose a risk for those on Monoamine Oxidase Inhibitors (MAOIs).

Call upon the Observer if you are paranoid. It knows that you have taken a drug and your old Survivor part is still living in the jungle thinking danger is everywhere. Your perceived hostility of the world is a projection of negative judgements abt yourself externalized. Some part of you thinks you are bad, worthy of punishment. Allow the paranoia to be a teacher. Alexander Shulgin lived his life in a unique position where his expertise in the field of mind altering drugs gave him the freedom to dance the lines of legality in the design, synthesis, and consumption of new substances.

Tryptamines i Have Known And Loved:

The toxicity and long-term health effects of recreational 2C-B use have not been studied in any scientific context, and the exact toxic dose is unknown.

Interestingly though, the most common report is that there is practically no next-day comedown or hangover and that the whole experience is much more gentle than its cousins MDMA and LSD. “LSD-like visuals but without the ‘head games’ that sometimes comes with traditional psychedelics,” is how Raquel described it. Plus, many say they don’t feel the “serotonin dump” or depressive come-down that can follow an MDMA experience. Papaseit, E.; Farré, M.; Pérez-Mañá, C.; Torrens, M.; Ventura, M.; Pujadas, M.; de la Torre, R.; González, D. (2018). "Acute Pharmacological Effects of 2C-B in Humans: An Observational Study". Frontiers in Pharmacology. 9: 206. doi: 10.3389/fphar.2018.00206 . ISSN 1663-9812. OCLC 1198838203. PMC 5859368 . PMID 29593537. While reading this book I attended a lecture given by Nobel laureate Kary Mullis. Kary Mullis received the Nobel Prize for Chemistry in 1993 for the development of PCR. During his lecture he commented on the first scientific paper he published in Nature, in 1968. He described it as a sophomoric astrophysical hypothesis called "The Cosmological Significance of Time Reversal." He told the audience he ate LSD while writing it. Needless to say Nature is still probably a little embarrassed about publishing it. Alexander Shulgin was a researcher of psychotropics which he had been inventing in his laboratories and testing on himself for almost half a century. Actually, no; merely calling him that would be like describing J.S. Bach simply as a Baroque musician. If it wasn't for him, a great many psychoactive compounds, including MDMA, the tremendous potential for psychotherapeutic use of which it was also he who discovered, would have never seen the light of day; people wouldn't have enjoyed them and found insight in their use... The field as a whole would be much poorer. The most compelling insight of that day was that this awesome recall had been brought about by a fraction of a gram of a white solid, but that in no way whatsoever could it be argued that these memories had been contained within the white solid. Everything I had recognized came from the depths of my memory and my psyche. I understood that our entire universe is contained in the mind and the spirit. We may choose not to find access to it, we may even deny its existence, but it is indeed there inside us, and there are chemicals that can catalyze its availability.”

Every drug opens a different door. An explorer should do this safely in time with guidance from veteran explorers United Kingdom: 2C-B is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause. [40] In 1994, two years after PIHKAL was published, the Drug Enforcement Administration (DEA) raided Shulgin's lab and requested that he turn over his DEA license. Richard Meyer, spokesman for DEA's San Francisco Field Division, has stated in reference to PIHKAL "It is our opinion that those books are pretty much cookbooks on how to make illegal drugs. Agents tell me that in clandestine labs that they have raided, they have found copies of those books," suggesting that the publication of PIHKAL and the termination of Shulgin's license may have been related. [1] Notable compounds [ edit ] Essential amphetamines [ edit ] How I rate this book is on a scale of 0 to awesome. But that doesn't mean it is without flaws or strangeness.

Armstrong, B. D.; Paik, E.; Chhith, S.; Lelievre, V.; Waschek, J. A.; Howard, S. G. (October 26, 2004). "Potentiation of (DL)‐3, 4‐methylenedioxymethamphetamine (MDMA)‐induced toxicity by the serotonin 2A receptor partial agonist d‐lysergic acid diethylamide (LSD), and the protection of same by the serotonin 2A/2C receptor antagonist MDL 11,939". Neuroscience Research Communications. 35 (2): 83–95. doi: 10.1002/nrc.20023. eISSN 1520-6769. Brazil: 2C-B is illegal to possess, produce and sell in Brazil as it is listed on Portaria SVS/MS nº 344. [25] Alexander Shulgin; Ann Shulgin (1991). PiHKAL: A Chemical Love Story. United States: Transform Press. ISBN 0963009605. OCLC 1166889264. The dosage of 2C-B is in the milligram region and the effects are highly dose dependent. There is a very steep dose response curve, which means that small changes to the dose that may be undetectable by eye could have drastic effects on the 2C-B experience. Alexander Shulgin states in PiHKAL that “over the 12 to 24 milligram range, every 2 milligrams can make a profound increase or change of response.” Therefore, it is critical that doses are measured accurately.B was discovered in 1974 by the American chemist Alexander Shulgin, who was investigating psychedelic phenethylamines derived from mescaline. [2] [3] Certain poly-drug mixes can increase risks, and it is not advised to mix MAOI antidepressants, lithium, or tramadol with 2C-B. Cannabis and amphetamines are also known to interact negatively, possibly intensifying the experience and increasing users’ anxiety, paranoia and negative thought loops. If you are set on experimenting with the 2C-B and cannabis combination, keep both doses lower than usual and spread out your cannabis intake by at least an hour or more before re-dosing.