VitaThrive® Sodium Bicarbonate 500mg – 90 Capsules

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You are on a salt (sodium) restricted diet, since each capsule contains 137 milligrams(mg) of sodium (see section 6 - Further information) Some antacids also contain other medicines, such as an alginate (which coats your gullet with a protective layer) and simeticone (which reduces flatulence). How and when to take antacids Each capsule contains Sodium Bicarbonate 500 mg. Equivalent to 137 mg of Sodium. For excipients, see 6.1. 3 PHARMACEUTICAL FORM Product licence holder: Dalkeith Laboratories Ltd., 2 Park Street, Woburn, Bedfordshire, MK17 9PG, UK. The manufacturers state that sodium bicarbonate should only be used during pregnancy if treatment is clearly necessary. Orally administered sodium bicarbonate is well absorbed and readily crosses the placental barrier. Existing blood pressure dysregulation, such as the physiological respiratory alkalosis associated with pregnancy, may also be increased due to the sodium load. The potential risk is unknown. Lactation

Overall, supplementation with sodium bicarbonate can enhance performance in high-intensity single- and multiple-bout exercise that last between about 30 seconds and 12 minutes. [1]Serum Bicarbonate - L Mc Naughton, D Thompson Acute versus chronic sodium bicarbonate ingestion and anaerobic work and power output J Sports Med Phys Fitness. (2001 Dec) Take Sodium Bicarbonate on an empty stomach, at least 1 hour before or 2 hours after a meal. What should I do if I have forgotten to take this medicine? DO NOT double a dose under any circumstances. Oral administration of sodium bicarbonate causes neutralisation of gastric acid with the production of carbon dioxide. The remaining bicarbonate is absorbed and, in theabsence of a deficit of bicarbonate in the plasma, bicarbonate ions are excreted, alongwith sodium ions, in the urine which is rendered alkaline and there is anaccompanying diuresis. 5.3 Preclinical safety data Do not take a double dose to make up for a forgotten dose, just carry on with the normal routine. 4. Possible side effects

For use for management of hyperphosphataemia in dialysis patients with serum phosphate levels that are not controlled after calcium based binder and sevelamer have been tried or in patients intolerant to other agents Many different types of antacid are available. Some are sold under a brand name and others are named after their main ingredient. Brands include Gaviscon (alginic acid) and Pepto-Bismol (bismuth subsalicylate). Serum Bicarbonate - Bouissou P, Defer G, Guezennec CY, Estrade PY, Serrurier B Metabolic and blood catecholamine responses to exercise during alkalosis Med Sci Sports Exerc. (1988 Jun) Warning. Do not exceed the stateo dose. KltP OUT OF THE SIGHT AND REACH OF CrilLDRtd. Do not store above 25°C.

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Serum Bicarbonate - Kilding AE, Overton C, Gleave J Effects of caffeine, sodium bicarbonate, and their combined ingestion on high-intensity cycling performance Int J Sport Nutr Exerc Metab. (2012 Jun) Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Serum Bicarbonate - Kozak-Collins K, Burke ER, Schoene RB Sodium bicarbonate ingestion does not improve performance in women cyclists Med Sci Sports Exerc. (1994 Dec)

Rate of Perceived Exertion - Hunter AM, De Vito G, Bolger C, Mullany H, Galloway SD The effect of induced alkalosis and submaximal cycling on neuromuscular response during sustained isometric contraction J Sports Sci. (2009 Oct) Alternatives: (TLS Blue) Calcichew ® (calcium carbonate) chewable tablet Calcium 500 ® (calcium carbonate) tablet Based on this, absorption of sodium hydrogen carbonate from a total of 12 capsules of 0.5 g each sets in after about 2 hours, peak changes in the acid-base status are seen after approximately 5-8 hours and, in correlation to this, renal elimination of Na + and base equivalents is greatest at this time. Bicarbonate Sodium bicarbonate 500mg capsules (TLS Green) Sodium bicarbonate injection/infusion 1.26%, 2.7%, 8.4% (TLS Green) A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/ tongue/throat), severe dizziness, trouble breathing.You have an allergic reaction (symptoms may include difficulty in breathing; closingof the throat; swelling of the lips, tongue or face) Possible side effects Anaerobic Capacity - Price MJ, Simons C The effect of sodium bicarbonate ingestion on high-intensity intermittent running and subsequent performance J Strength Cond Res. (2010 Jul) Power Output - Nielsen HB, Bredmose PP, Strømstad M, Volianitis S, Quistorff B, Secher NH Bicarbonate attenuates arterial desaturation during maximal exercise in humans J Appl Physiol. (2002 Aug) Manufacturer: Aspar Pharmaceuticals Ltd, 29-30 Capitol Way, Capitol Way Industrial Park, Colindale, have liver disease, kidney disease or heart failure – some antacids may not be safe if you have one of these problems

Insulin - Harris SS, Dawson-Hughes B No effect of bicarbonate treatment on insulin sensitivity and glucose control in non-diabetic older adults Endocrine. (2010 Oct) Sodium chloride with other ingredients Sodium chloride 0.18% / glucose 4% intravenous infusion (TLS Green) Discuss your treatment with your doctor before taking this medicine if any of the above applies to you. Taking other medicines Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.Power Output - Kupcis PD, Slater GJ, Pruscino CL, Kemp JG Influence of sodium bicarbonate on performance and hydration in lightweight rowing Int J Sports Physiol Perform. (2012 Mar) This medication can decrease the effectiveness of certain drugs that need stomach acid to work, including ampicillin, atazanavir, certain azole antifungals (such as ketoconazole, itraconazole), iron supplements, pazopanib, sucralfate, among others. Before using this medication, ask your doctor or pharmacist how to manage this possible interaction. You can drink alcohol while taking antacids, but alcohol can irritate your stomach and make your symptoms worse. Side effects of antacids Some health effects (increase in metabolic rate or attenuation of metabolic acidosis) can be achieved at more reasonable doses, such as 5-10 g, and may be more practical for nonathletes. If you forget to take your capsules, take the next dose as soon as you remember. Do not take a double dose to make up for forgotten doses.