Herbal Magic's Pure & Natural Blend - Biotin Powder (10,000 mcg in 1 Scoop) - UKAS LAB Tested in UK - Made from 14 x Fruits, Vegetables & Herbs - No fillers/Preservatives/Color/Maltodextrin-Pack of 1

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Tourbah A, Lebrun-Frenay C, Edan G, et al. MD1003 (High-Dose Biotin) for the Treatment of Progressive Multiple Sclerosis: A Randomised, Double-Blind, Placebo-Controlled Study. Mult Scler. 2016;22(13):1719-1731. View abstract.

It’s also worth noting that if you have ‘extra’ biotin in your body, it will naturally be flushed out of your system when you urinate. Children: Biotin is likely safe when taken by mouth. It's been used safely in doses of 5-25 mcg daily.Biotin doesn’t appear to be linked to any notable side effects. Some people report skin rashes or digestive upset after taking a biotin supplement, but there’s currently no research on specific biotin side effects.

Together with other B vitamins, biotin also supports normal psychological and nervous system function 7 by helping to maintain neurons in the brain. There is no current ‘recommended’ intake for biotin like there is for many other vitamins like vitamin C and vitamin D, as more research is needed.Branger P, Parienti JJ, Derache N, Kassis N, Assouad R, Maillart E, Defer G. Relapses During High-Dose Biotin Treatment in Progressive Multiple Sclerosis: a Case-Crossover and Propensity Score-Adjusted Prospective Cohort. Neurotherapeutics. 2020. View abstract. Said HM. Biotin: biochemical, physiological and clinical aspects. Subcell Biochem 2012;56:1-19. [ PubMed abstract] No evidence in humans has shown a toxicity of biotin even with high intakes. Because it is water-soluble, any excess amount will leave through the urine. There is no established upper limit or toxic level for biotin. Did You Know? Pregnant or breastfeeding women often benefit from a prenatal vitamin,” says Barth. “Prenatal vitamins contain biotin, folic acid and other nutrients that are important for the health of the mother and baby. If you’re not sure which prenatal vitamin to take, ask your provider.” Do biotin supplements help with hair growth? Biotin supplements are often glamorized as a treatment for hair loss and to promote healthy hair, skin, and nails. Although a deficiency of biotin can certainly lead to hair loss and skin or nail problems, evidence showing a benefit of supplementation is inconclusive. A handful of case reports and small trials have shown a benefit, but the study designs had weaknesses:

Baez-Saldana A, Zendejas-Ruiz I, Revilla-Monsalve C, et al. Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers for glucose and lipid homeostasis in type 2 diabetic patients and nondiabetic subjects. Am J Clin Nutr 2004;79:238-43. View abstract. A limited number of reliable indicators of biotin status is available [ 7]. In healthy adults, the concentration of biotin is 133–329 pmol/L in serum and 18–127 nmol/24 hours in urine [ 2]. Abnormally low urinary excretion of biotin is an indicator of biotin deficiency, as is abnormally high excretion of 3-hydroxyisovaleric acid (higher than 3.3 mmol/mol creatinine) or 3-hydroxyisovalerylcarnitine (higher than 0.06 mmol/mol creatinine) resulting from reduced activity of MCC [ 2, 7, 8]. The most reliable individual markers of biotin status, including deficiency and sufficiency, are biotinylated MCC and propionyl-CoA carboxylase in white blood cells [ 7]. Oral administration of large doses of biotin increases serum concentrations of biotin and its metabolites [ 1, 9]. However, serum concentrations of biotin and its catabolites are not good indicators of marginal biotin deficiency because they do not decrease sufficiently in people with marginal biotin deficiency for these changes to be detectable with existing tests [ 3, 10]. Recommended Intakes

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Allergies and dietary needs. Also consider any allergies or dietary considerations you may have. Klaire Labs and Pure Encapsulations offer hypoallergenic biotin supplements, while Garden of Life offers organic, vegan-friendly options. Supporting energy metabolism – biotin helps to convert the proteins, fats and carbs from our food into energy. Keep in mind that there’s little evidence to support the use of biotin for hair, nail, or skin health. Consuming a healthy, well-rounded diet will do much more for your hair, skin, and nails than taking a supplement. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. View abstract.