Anatomy of a Breakthrough: How to get unstuck and unlock your potential

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Work Like Da Vinci: Gaining the Creative Advantage in Your Business and Career by Michael Gelb (2006) Coronavirus infections are happening among vaccinated people. They’re going to keep happening as long as the virus is with us, and we’re nowhere close to beating it. When a virus has so thoroughly infiltrated the human population, post-vaccination infections become an arithmetic inevitability. As much as we’d like to think otherwise, being vaccinated does not mean being done with SARS-CoV-2. A few months before, the woman had terminal cancer, but she had just been told that she was in remission. Today, more than a decade later, she remains cancer free and works as a fitness instructor. It was a breakthrough of monumental proportions and one that would make Allison world famous.

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The road to breakthroughs is a series of Zen paradoxes. One of my favorites is the idea that pausing is the best way to move forward in the long run. The idea here is to take a beat—whether a minute or a day or a week—before you act. Alter was recently included in the Poets and Quants “40 Most Outstanding Business School Professors under 40 in the World,” and has written for the New York Times, New Yorker, Wired, Washington Post, and The Atlantic, among other publications. He has shared his ideas at the Cannes Lions Festival of Creativity and with dozens of companies around the world. By the mid 1990s, due to the work of hundreds of scientists, a working model of immune regulation had been established. One receptor, called B-7 works much like the ignition switch in a car, initiating the immune response while another, CD-28 acts as a gas pedal, stimulating the body to produce T-cells at a furious rate. Adam Alter marries research-based solutions with genuine insight. This book is an invaluable guide to turning hurdles into breakthroughs." —Scott Galloway, NYU Stern professor of marketing and author of Adrift In Zen terms, do what Messi and Agassi do: slow down now to make progress later. 4. Think like a curious child by adopting an experimental mindset.It’s tempting to surround yourself with people who are both competent and similar to yourself, but that’s a mistake. The best way to capitalize on the value of other people is to consult with those who are fundamentally different from you. Jim Allison’s journey began a long time before he walked into that office. When he was finishing up his graduate work in the early 1970s, researchers had just discovered T-cells, which were largely a mystery at the time. Allison, who told me that he always liked “figuring things out,” was intrigued and thought the immune system was something he could spend his career studying. There’s a potential silver lining to breakthroughs as well. By definition, these infections occur in immune systems that already recognize the virus and can learn from it again. Each subsequent encounter with SARS-CoV-2 might effectively remind the body that the pathogen’s threat still looms, coaxing cells into reinvigorating their defenses and sharpening their coronavirus-detecting skills, and prolonging the duration of protection. Some of that familiarity might ebb with certain variants. But in broad strokes, a post-inoculation infection can be “like a booster for the vaccine,” Su, of the University of Pennsylvania, told me. It’s not unlike keeping veteran fighters on retainer: After the dust has settled, the battle’s survivors will be on a sharper lookout for the next assault. That’s certainly no reason to seek out infection. But should such a mishap occur, there’s a good chance that “continuously training immune cells can be a really good thing,” Nicole Baumgarth, an immunologist at UC Davis, told me. (Vaccination, by the way, might mobilize stronger protection than natural infection, and it’s less dangerous to boot.)

ANATOMY OF A BREAKTHROUGH — Adam Alter

A deeply researched and compelling guide to breaking through the inevitable obstacles on the path to meaningful accomplishment."— Cal Newport, New York Times bestselling author of Digital Minimalism and Deep Work La solución propuesta por el autor se basa en un proceso que él llama: auditoría de fricción, un procedimiento sistemático para entender por qué una persona u organización está estancada y cómo avanzar superando tres fuentes de fricción: las emociones inútiles, los patrones de pensamiento inútiles y los comportamientos inútiles. These four attributes, deep domain expertise, skepticism, persistence and a collaborative approach don’t guarantee a breakthrough, but one rarely happens without them. A new dichotomy has begun dogging the pandemic discourse. With the rise of the über-transmissible Delta variant, experts are saying you’re either going to get vaccinated, or going to get the coronavirus . Over the next two decades, he became a highly respected researcher and made some notable discoveries in the field of immune regulation. It was slow, painstaking work, identifying the myriad different receptors that govern the human immune system, decoding the structure of their proteins and inferring how they functioned together.A deeply researched and compelling guide to breaking through the inevitable obstacles on the path to meaningful accomplishment." —Cal Newport, New York Times bestselling author of Digital Minimalism and Deep Work Striking research showing the immense complexity of ordinary thought and revealing the identities of the gatekeepers in our minds. Prepped by a vaccine, immune reinforcements will be marshaled to the fore much faster—within days of an invasion, sometimes much less. Adaptive cells called B cells, which produce antibodies, and T cells, which kill virus-infected cells, will have had time to study the pathogen’s features, and sharpen their weapons against it. While the guard dogs are pouncing, archers trained to recognize the virus will be shooting it down; the few microbes that make their way deeper inside will be gutted by sword-wielding assassins lurking in the shadows. “Each stage it has to get past takes a bigger chunk out” of the virus, Bhattacharya said. Even if a couple particles eke past every hurdle, their ranks are fewer, weaker, and less damaging. On the curiosity spectrum, you have children on the one end, constantly asking questions about everything. On the other end, you have adults, who assume things are the way they are for a reason. Adults question very little, and so we tend to herd together, doing most things the same way as other people do them. The exceptions—adults who ask questions like children—are known as experimentalists. They question everything. Sometimes they come to agree that a popular approach has merit, but often they stumble on superior alternatives. In art, music, writing, and business, the holy grail is an original idea—something revolutionary that no one’s considered before. The problem with ideas that appear revolutionary is that they’re almost never truly original. Instead, they’re what’s known as recombinations—the marriage of two old ideas to form something evolutionarily different. “When striving for new ideas, do as Dylan did by taking two or more good but disparate concepts, and seeing if you can merge them to form a novel recombination.”