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This Research Topic collected significant contributions to the advancement of the motor-cognitive interplay. The integrative use of novel neuroscientific techniques strives for an in-depth investigation of motor behavior, assuming a multidisciplinary approach to the study of brain–behavior relations also in neurological populations. This will enable neuroscientific knowledge to be effectively translated for clinical practice. Author contributions From an applied biomechanics perspective, this work promotes the adoption of integrated instrumented approaches to motor performance assessment. The abundance of main effects for session, in both instrumented locomotion tasks, highlights how the IMU-based biomarkers could support the evaluation of the efficacy of the rehabilitative treatment, whether it is conventional or vestibular. The added value of our instrumented protocol is in the fact that we can go far beyond a global collective score (as happens in the clinical tests), giving the clinician the opportunity to objectively examine subtle improvements in gait quality from different domain perspectives (such as gait stability and smoothness, for instance). In December 2021, BELLUS announced positive data from the SOOTHE phase IIb trial, indicating that it met its primary endpoint for the 50 mg and 200 mg twice-daily doses. Based on these data, BELLUS initiated the CALM phase III development programme consisting of the CALM-1 and CALM-2 trials, with data anticipated in H2 2024 and 2025, respectively. BELLUS is also evaluating a QD (once-daily) formulation for camlipixant, which is currently in phase I. For over 50 years, GSK has led the way in developing medicines that advance the management of asthma and COPD, from introducing the world’s first selective short-acting beta agonist in 1969 to launching six treatments in five years to create today’s industry-leading respiratory portfolio. About RCC Seagrass presence depends on a number of factors such as physical variables (e.g. temperature, salinity, depth, turbidity) which regulate its physiological activity, natural phenomena (climate change) and anthropogenic pressures. Meadows cover the majority of the Western Mediterranean coasts, but they are absent along parts of the Spanish coastline (Tarragona region), near the Ebro’s mouth, where freshwater input affects salinity and turbidity, thereby hindering seagrass growth 35. Similarly, along the French coasts between the Albères coastline and the Rhone River’s mouth (except for small beds in Cape d’Adge), considerable contributions of freshwater, suspended sediment and organic matter input do not allow P. oceanica to develop into meadows 36. Posidonia oceanica is also absent in Morocco (except for the Chafarinas Islands), probably due to the influence of cold Atlantic Water. In the Adriatic Sea, meadows are distributed along the eastern part (the coastline of Slovenia, Croatia, Montenegro and Albania) 37, the Apulian coasts 38 and small patches are present in Friuli (north-east of Italy) 39. In the North and Central-Western Adriatic Sea (Italian coasts of Abruzzi, Marche, Emilia and Veneto), inputs of suspended sediment and dissolved organic matter from the Po’s outlet, create high levels of turbidity along the central-western Adriatic coast, all the way until the Gargano Promontory. In the Levant Sea (Syrian, Lebanese and Israeli coastline), early reports of P. oceanica should be considered erroneous because meadows are not present in this area.
Department of Fisheries and Aquaculture, Fisheries Resource Unit, Ministry for Sustainable Development, the Environment and Climate Change (MSDEC-FRU), Ghammieri, Marsa, MRS 3303, Malta Hazan, L., Zugaro, M. & Buzsáki, G. Klusters, NeuroScope, NDManager: a free software suite for neurophysiological data processing and visualization. J. Neurosci. Methods 155, 207–216 (2006). Institute of Oceanography, Hellenic Centre for Marine Research, PO box 712, Anavyssos, 19013, Greece
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article. Conflict of interest Meltzer et al. Prevalence and Burden of Chronic Cough in the United States. J of Allergy Clin Immunol Pract. 2021; 9:4037-44. Citation: Belluscio V, Betti V, Martino Cinnera A and De Bartolo D (2023) Editorial: The brain meets the body: neural basis of cognitive contribution in movement for healthy and neurological populations. Front. Hum. Neurosci. 17:1306252. doi: 10.3389/fnhum.2023.1306252 Stability: Normalized Root Mean Square ( nRMS) of the acceleration measured at pelvis, trunk, and head levels. The values were obtained for the AP, ML, and CC signal components as well as the magnitude value. High nRMS values have been associated with higher levels of acceleration, and hence, decreased stability [ 42]; Laboratory of Marine Biology, Department of Biological and Environmental Science and Technologies, University of Salento – CoNISMa, Lecce, 73100, Italy
Pergent, G. La protection légale de la Posidonie en France: un outil efficace. Nécessité de son extension a d’autres pays méditerranéens in Les Espèces Marines a Protéger en Méditerranée: Rencontres scientifiques de la Cote Bleue (eds Boudouresque, C. F., Avon, M. & Gravez, V. ) 29–34 (GIS Posidonie, 1991). Most of the spatial data were not available in geo-referenced digital format (e.g. shapefile, raster file) suitable for graphic software (e.g. ArcGIS, AutoCAD), but as paper maps only such as .jpeg and .pdf. The maps available had a great heterogeneity of spatial resolution, ranging from 1:1,000 to 1:250,000. Collated maps were characterised by various geographical projections, datum and legends, with a suite of non-standardised symbology. As a consequence, paper maps were manually digitized, the new maps geo-referenced (UTM Projection with WGS 1984 Datum) and incorporated in a GIS database (see Fig. 6 and Supplementary Figure S1 online). A loss of 30% of the meadows was reported along the Ligurian coasts since the 1960 s 20, whereas our estimate was 19%. In France, a P. oceanica regression of 23% was reported over the last 50 years, or, in more detail, 2% in Corsica (Cap Corse) in the last 15 years, 9.5% since the 1960’ (St. Florent), 4.3–5% in Marseille-Cortiou 49 and 90% along the coast of Marseille in the last 100 years 11. Our estimate for the French continental coast is equal to an average of 9%. In those cases where estimates differ, discrepancies are likely due to problems of accuracy of historical maps, which were identified by authors working in these areas 14, 20, 21. Board Certified: Cardiovascular Disease, Nuclear Cardiology, Critical Care Medicine, Internal Medicine Thirty sTBI inpatients were enrolled based on consecutive sampling within a six-month time window. This sample size met the minimum requirement set by an a priori power analysis for nonparametric between-group comparisons conducted on preliminary data (α = 0.05; β = 0.8; ES = 0.6) [ 30]. According to this sample size estimation procedure, each group should have had at least 13 patients. All participants were at their first neurorehabilitation admission since trauma. Almost all the patients selected suffered from sTBI as a consequence of a traffic accident, whereas two people suffered from sTBI due to a fall off a horse. Inclusion criteria were: aged between 15 and 65 years, Level of Cognitive Functioning (LCF) ≥ 7 [ 31]. Prior traumatic brain injury, cognitive deficits affecting comprehension of task instructions (Mini-Mental State Examination score of 24), severe unilateral spatial neglect (diagnosed using a battery of tests including the Letter Cancellation Test, Barrage Test, Sentence Reading Test, and Wundt–Jastrow Area Illusion Test), and severe aphasia, the presence of other neurological and psychiatric diseases, and the presence of orthopaedic or cardiac comorbidities that would limit participation in the experimental and conventional training were the exclusion criteria.To examine the waveform of CA1 theta oscillations, we first applied a broad bandpass filter (1–80 Hz) and determined local minima and maxima in the theta range. Local minima and maxima were then used to determine the duration of the ascending and descending part of the theta cycle to calculate the asymmetry index. For the determination of theta waveshape phases, we calculated the median LFP over all CA1 recording channels that were sufficiently correlated (threshold, r> 0.7) to avoid inclusion of channels with strong phase shifts. From this median LFP signal, local minima and maxima were determined to extract the waveform phase by linear interpolation between them, with minima equaling 0° and maxima equaling 180°. With this approach, independent of the length of the ascending and descending parts of the theta cycle, each part always covers 180°. Other phase estimates and phase precession analyses were done as described previously ( Schmidt et al., 2009). Arnaud-Haond, S. et al. Implications of extreme life span in clonal organisms: millenary clones in meadows of the threatened seagrass Posidonia oceanica. PLoS One 7, e30454 (2012).
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