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It’s known that inflammation and oxidative damage play a role in Alzheimer’s disease, and curcumin has beneficial effects on both. Synergistic antitumor efficiency of docetaxel and curcumin against lung cancer,” Acta Biochimica et Biophysica Sinica, vol. Turmeric hinders Bacillus subtilis and Escherichia coli growth by restraining filamenting temperature-sensitive mutant Z (FtsZ) (cytoskeletal protein) assembly through repressing the FtsZ polymerization [ 89].
Nirmala Menon, “Process development for the enrichment of curcuminoids in turmeric spent oleoresin and its inhibitory potential against LDL oxidation and angiotensin-converting enzyme,” International Journal of Food Sciences and Nutrition, vol. Apoptotic death in curcumin-treated NPC-TW 076 human nasopharyngeal carcinoma cells is mediated through the ROS, mitochondrial depolarization and caspase-3-dependent signaling responses,” International Journal of Oncology, vol. Also, there are a number of clinical trials about the efficacy of curcumin on cardiovascular risk factors [ 126– 128]. J. Lapidus, “Curcumin prevents aggregation in α-synuclein by increasing reconfiguration rate,” Journal of Biological Chemistry, vol. Turmeric performs antitumor and anticancer functions through the inhibition of NF- κB establishment and downregulation of NF- κB-related gene products associated with endurance, propagation, and metastasis of cancer cells.
V. Kumar, “Purely aqueous PLGA nanoparticulate formulations of curcumin exhibit enhanced anticancer activity with dependence on the combination of the carrier,” International Journal of Pharmaceutics, vol. That said, there are plenty of other ways to get it, too — such as in moisturizers, eye creams, and face masks. It has been shown that oxidative stress and distressed protein metabolism and their interaction are central to AD pathogenesis [ 107].
A study exploring turmeric extract supplementation for knee osteoarthritis found that turmeric effectively reduces inflammation and relieves pain. Skin tone: The serum is effective in color correcting and maintaining an even skin tone on your body. Heydari, “Efficacy of cinnamon in patients with type II diabetes mellitus: a randomized controlled clinical trial,” Clinical Nutrition, vol.L-ascorbic acid refines skin texture while salicylic acid comes into play to gently exfoliate clogged pores — making it ideal for those with oily skin. Feria-Velasco, “Curcumin protects against the oxidative damage induced by the pesticide parathion in the hippocampus of the rat brain,” Nutritional Neuroscience, vol. Curcumin, the primary polyphenol (health-boosting) compound in turmeric, may benefit joint health and help manage symptoms of arthritis. Heart disease is a leading cause of death globally, accounting for 1 in 5 deaths in the United States alone. A. Langhans, “Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosis,” BMC Cancer, vol.
In fact, it stimulates AMP-activated kinase by lessening the appearance of COX-2 protein and represses the nuclear factor- κB (NF- κB) action on the mucosa of the colon. Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting. The antioxidant ability of turmeric resulted in decreased levels of prostaglandin E2 (as a marker of oxidative stress) in HepG2 cells [ 66].Furthermore, if you’re allergic to turmeric or any of the ingredients of the serum, you can other dark spot correcting serums available. Results of a study on a novel intravenously injectable curcumin revealed that rabbits in curcumin nanosuspension group developed local irritation and phlebitis risks and erythrocyte hemolysis lesser than those in curcumin solution group [ 139]. Plants and their products having neuroprotective effects might be a novel therapeutic approach to treat Parkinson’s disease (PD) [ 100, 101].
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